Figure 7. Schematic diagram of the molecular action of 2MeOE₂.

2MeOE₂ -mediated pro-apoptotic actions involve the catalytic activation of PKCδ by cellular caspases. The catalytic fragment of PKCδ is responsible for the apoptotic histone modifications in the nucleus and activates p38 MAPK pathway in the cytosol, which induces more activation of caspases that consequently cleave and activate more PKCδ. Therefore this cycle accelerates and amplifies the 2MeOE₂-mediated apoptotic signal.