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. 2020 Sep 25;11:520486. doi: 10.3389/fphar.2020.520486

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Copyright © 2020 Xiao, Oumarou, Wang and Liu

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The effects of Malva sylvestris L. on circular RNA expression. (A) cirRNA expression profiles in I/R rat model with or without MS pre-treatment. (B) qPCR was performed to measure the expression of circ_003593 in H9c2 cells after OGD/Re treatment. (C) circ_003593 was knocked down by shRNA transfection. (D) CCK-8 was performed to determine the cell viability in H9c2 cells after indicated treatment. (E) Flow cytometry was performed to determine the apoptotic cell in H9c2 cells after indicated treatment. (F) Western blot was performed to determine the expression of NLRP3, ASC, and cleaved caspase 1 in H9c2 cells after indicated treatment. *p < 0.05, **p < 0.01, and ***p < 0.001. MS, Malva sylvestris L.; NS, normal saline; I/R, ischemia-reperfusion; KD, knockdown; OGD/Re, oxygen glucose deprivation/reoxygenation; ASC, adapter apoptosis-associated speck-like protein containing a C-terminal caspase recruitment domain.