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. 2020 Sep 25;11:559342. doi: 10.3389/fimmu.2020.559342

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Copyright © 2020 Korvatska, Kiianitsa, Ratushny, Matsushita, Beeman, Chien, Satoh, Dorschner, Keene, Bammler, Bird and Raskind.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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TREM2 R47H AD features upregulated interferon type I response and MHC class I-like NKG2D ligands. (A) Role of RIG1-like receptors in antiviral innate immunity, Ingenuity Pathway Analysis-generated diagram shows perturbed gene expression in TREM2 R47H AD brains. Red denotes upregulated genes; gray, not changed compared to control brains; white, not assessed. Perturbed expression (FDR < 0.1) of IFN I type response/antiviral genes (B) and MHC class I-like NKG2D ligands. (C) Data are presented as mean ± SD (^∗adj p-value < 0.05; ^∗∗adj p-value < 0.01); y-axis displays log2 (FC, fold changes) value.