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. 2020 Sep 24;10:434. doi: 10.3389/fcimb.2020.00434

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Copyright © 2020 Zhou, Zhang, Cui, Luo, Chen, Liang, Jiang, Ning, Tian, Zhong, Ye, Liang and Huang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Forest plots comparing MSM to non-MSM (NonMSM) individuals. Before controlling for other confounding factors, the alpha diversity of the MSM was significantly lower than that of the non-MSM individuals (a, Simpson index). When restricting the analysis to HIV+ (b, Fisher index), age ≥45 years (e, Fisher index), BMI = 24–27.9 (f, Fisher index) individuals, MSM status was associated with an increase in alpha diversity. When restricting the analysis to HIV– individuals (c, Invsimpson index) and age <45 years (d, Invsimpson index), MSM status was associated with a significant decrease in alpha diversity.