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. 2020 Sep 25;11:532199. doi: 10.3389/fphar.2020.532199

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Copyright © 2020 Safar, El-Hashim, Amoudy and Mustafa

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effect of Rv3619c/Freund’s Incomplete Adjuvant (IFA) alone and in combination with low dose dexamethasone (DEX) (0.5 mg) treatment on sera levels of ovalbumin (OVA)-specific IgE (A) IgG (B) and IgG1 (C) from OVA-challenged mice. Immunization with Rv3619c/IFA alone resulted in significant reduction in the sera levels of OVA-specific IgE, IgG, and IgG1. Immunization with Rv3619c/IFA alone or in combination with dexamethasone (0.5 mg) treatment did have any greater effects on the OVA-specific IgE, IgG, and IgG1. Data are expressed as mean ± SEM (n = 10). ^#P < 0.05 versus time-matched PBS-challenged mice. *P < 0.05 versus time-matched OVA-challenged mice. **P < 0.05 versus Rv3619c/IFA and dexamethasone (0.5 mg).