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. 2020 Sep 11;133(19):2321–2329. doi: 10.1097/CM9.0000000000001075

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Copyright © 2020 The Chinese Medical Association, produced by Wolters Kluwer, Inc. under the CC-BY-NC-ND license.

This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc-nd/4.0

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TOP2A is overexpressed and promotes cell proliferation in gallbladder cancer cell lines. (A) Relative mRNA and protein expression of TOP2A in GBC cell lines (NOZ, SGC-996, GBC-SD, and OCUG) and human renal epithelial cell line 293T. (B and C). Knockdown and overexpression efficiency of TOP2A in GBC cell lines were measured by quantitative reverse transcription polymerase chain reaction and Western blotting, respectively. (D) Cell proliferation of GBC cell lines was detected by cell counting kit-8 assay. ^∗P < 0.05. GAPDH: Glyceraldehyde-3-phosphate dehydrogenase; NC: Negative control; SIRNA: Small interfering RNA; TOP2A: Topoisomerase II alpha.