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. 2020 Sep 25;14:546659. doi: 10.3389/fncel.2020.546659

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Copyright © 2020 Noh, Oh, Park and Song.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Behavioral tests after intracerebral (IC) transplantation or intravenous (IV) injection of human umbilical cord-derived mesenchymal stromal cells (hUC-MSCs) in middle cerebral artery occlusion (MCAo) rats. (A) Schematic of experimental designs. (B) Rotarod tests in four study groups for 8 weeks after treatment. (C) Stepping test for 8 weeks. (D) mNSS test for 8 weeks. (E) Behavioral recovery rates for three behavioral tests. The recovery rate is defined as the percentage of the final score (Week 8) to the baseline score (Day 0). Cell transplantation (“TP”) performed 1 week after MCAo induction. All data expressed as mean ± SEM values. *p < 0.05; **p < 0.001 (IV saline group vs. IC hUC-MSC group); ^#p < 0.05; ^##p < 0.001 (IC saline group vs. IC hUC-MSC group); ^$p < 0.05; ^$$p < 0.001 (IV hUC-MSC group vs. IC hUC-MSC group) by mixed ANOVA.