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. 2020 Oct 9;9(10):e1154. doi: 10.1002/cti2.1154

Figure 2.

Figure 2

Cytotoxic effects of PD‐L1 CAR transduced T cells on lung carcinoma cells, as compared to the effects of PD‐1 fusion receptor T cells. The cell‐killing effects of PD‐1 fusion receptor (PD1‐CD28Z‐CD3zeta) T cells and PD‐L1 CAR‐T cells were investigated after co‐incubation with lung cancer cells in different effector to target ratios. CAR‐T cell killing by CD38 CAR cells, PD‐1 fusion receptor T cells and PD‐L1 CAR‐T cells were investigated after co‐incubation with lung cancer cells in different effector to target ratios (E:T = 3:1, 10:1 and 30:1, respectively). n = 3. (a–c) H1975 cells; (d–f) H3122 cells. CD38‐specific CAR‐T cells were included as the control. PD‐L1 CAR‐T cells were significantly more potent than PD‐1 fusion receptor T cells. One‐way ANOVA and the Student’s t‐test were used. *P‐value < 0.05；**P‐value < 0.01.