Table 3.
Exercise intervention effects on fatigue, total symptoms, symptom burden and QoL, stratified by sense of coherence
| Adjusted mean between-group difference (95% CI) | pinteraction (intervention × SOC) | Effect size | |||
|---|---|---|---|---|---|
| RT-HIIT vs UCa | AT-HIIT vs UCa | RT-HIIT vs UC | AT-HIIT vs UC | ||
| Cancer-related fatigue (PFS) | |||||
| Total CRFb | − 1.17 (− 2.18; − 20.16)* | − 0.72 (− 1.73; 0.30) | 0.88 | 0.39 | 0.25 |
| Weak-normal SOC | − 1.09 (− 2.30; 0.13) | − 0.87 (− 2.10; 0.36) | 0.36 | 0.30 | |
| Strong SOC | − 1.01 (− 2.90; 0.88) | − 0.44 (− 2.32; 1.45) | 0.39 | 0.21 | |
| Sensory/physical CRFb | − 1.22 (− 2.33; − 20.11)* | − 0.64 (− 1.76; 0.49) | 0.68 | 0.38 | 0.21 |
| Weak-normal SOC | − 1.16 (− 2.52; 0.20) | − 0.95 (− 2.32; 0.42) | 0.35 | 0.29 | |
| Strong SOC | − 0.97 (− 2.98; 1.04) | − 0.12 (− 2.14; 1.89) | 0.35 | 0.05 | |
| Behaviour/daily life CRFb | − 1.46 (− 2.55; − 20.37)* | − 0.96 (− 2.05; 0.14) | 0.98 | 0.47 | 0.36 |
| Weak-normal SOC | − 1.46 (− 2.78; − 20.14)* | − 1.07 (− 2.38; 0.25) | 0.45 | 0.37 | |
| Strong SOC | − 1.24 (− 3.27; 0.79) | − 0.80 (− 2.82; 1.23) | 0.49 | 0.40 | |
| Emotional/affective CRFb | − 1.10 (− 2.26; 0.06) | − 0.49 (− 1.66; 0.68) | 0.69 | 0.34 | 0.16 |
| Weak-normal SOC | − 0.78 (− 2.14; 0.58) | − 0.60 (− 1.97; 0.77) | 0.24 | 0.19 | |
| Strong SOC | − 1.37 (− 3.60; 0.86) | − 0.36 (− 2.60; 1.87) | 0.45 | 0.14 | |
| Cognitive CRFb | − 0.89 (− 1.81; 0.03) | − 0.70 (− 1.63; 0.23) | 0.91 | 0.31 | 0.27 |
| Weak-normal SOC | − 0.91 (− 2.04; 0.22) | − 0.78 (− 1.92; 0.36) | 0.31 | 0.28 | |
| Strong SOC | − 0.46 (−2.14; 1.22) | − 0.39 (− 2.06; 1.28) | 0.19 | 0.21 | |
| Symptoms (MSAS) | |||||
| Total symptomsb | − 0.20 (− 0.37; − 20.04)* | − 0.13 (− 0.30; 0.03) | 0.10 | 0.39 | 0.29 |
| Weak-normal SOC | − 0.24 (− 0.46; − 20.02)* | − 0.05 (− 0.27; 0.17) | 0.44 | 0.11 | |
| Strong SOC | − 0.07 (− 0.32; 0.18) | − 0.15 (− 0.40; 0.10) | 0.19 | 0.40 | |
| Symptom burdenb | − 0.22 (− 0.41; − 20.02)* | − 0.24 (− 0.43; − 0.04)* | 0.27 | 0.30 | 0.37 |
| Weak-normal SOC | − 0.24 (− 0.48; 0.01) | − 0.13 (− 0.38; 0.11) | 0.31 | 0.21 | |
| Strong SOC | − 0.10 (− 0.43; 0.22) | − 0.26 (− 0.49; 0.07) | 0.21 | 0.47 | |
| Health-related quality of life (EORTC-QLQ-C30) | |||||
| Global health status/QoLb | 5.47 (−1.74; 12.67) | 4.67 (− 2.60; 11.94) | 0.19 | 0.23 | 0.22 |
| Weak-normal SOC | 5.71 (−3.80; 15.21) | 1.00 (− 8.62; 10.62) | 0.25 | 0.05 | |
| Strong SOC | 4.33 (−7.29; 15.95) | 9.41 (− 2.28; 21.10) | 0.19 | 0.51 | |
CI confidence interval, PFS Piper Fatigue Scale, CRF cancer-related fatigue, MSAS Memorial Symptom Assessment Scale, QoL quality of life
aRT-HIIT: overall n = 74, weak-normal SOC n = 41, strong SOC n = 33. AT-HIIT: overall n = 70, weak-normal SOC n = 40, strong SOC n = 30
UC overall n = 60, weak-normal SOC n = 42, strong SOC n = 18. bTotal effects of the exercise interventions on fatigue, symptoms, and health-related quality of life have been previously reported [12]