Table 3.
Results of the multivariate analysis regarding the EORTC subscales and single items with content-driven-selected variables
| Subscale or symptom | Variable | Beta | p | 95% CI lower | 95% CI upper |
|---|---|---|---|---|---|
| Physf | Age ≥ 65 (yes/no) | − 0.126 | 0.029 | − 15.66 | − 0.84 |
| Time since diagnosis | 0.040 | 0.484 | − 0.53 | 1.12 | |
| KPS ≥ 70 (yes/no) | 0.526 | < 0.0001 | 30.73 | 47.35 | |
| gender | − 0.060 | 0.278 | − 10.58 | 3.05 | |
| Rolef | Age ≥ 65 (yes/no) | 0.015 | 0.815 | − 15.66 | − 0.84 |
| Time since diagnosis | 0.113 | 0.072 | − .53 | 1.12 | |
| KPS ≥ 70 (yes/no) | 0.416 | < 0.0001 | 30.73 | 47.35 | |
| Gender | − 0.033 | 0.592 | − 10.58 | 3.05 | |
| Emof | Age ≥ 65 (yes/no) | 0.102 | 0.130 | − 1.65 | 12.82 |
| Time since diagnosis | 0.030 | 0.650 | − 0.63 | 1.00 | |
| KPS ≥ 70 (yes/no) | 0.278 | < 0.0001 | 9.29 | 25.59 | |
| Gender | − 0.175 | 0.007 | − 15.86 | − 2.51 | |
| Cogf | Age ≥ 65 (yes/no) | − 0.084 | 0.205 | − 15.01 | 3.24 |
| Time since diagnosis | 0.071 | 0.280 | − 0.47 | 1.60 | |
| KPS ≥ 70 (yes/no) | 0.294 | < 0.0001 | 13.18 | 33.72 | |
| Gender | − 0.080 | 0.213 | − 13.75 | 3.08 | |
| Socf | Age ≥ 65 (yes/no) | 0.011 | 0.863 | − 8.60 | 10.24 |
| Time since diagnosis | 0.083 | 0.191 | − 0.37 | 1.77 | |
| KPS ≥ 70 (yes/no) | 0.408 | < 0.0001 | 24.14 | 45.48 | |
| Gender | − 0.065 | 0.294 | − 13.32 | 4.05 | |
| Fatigue | Age ≥ 65 (yes/no) | 0.057 | 0.391 | − 4.70 | 11.97 |
| Time since diagnosis | − 0.094 | 0.147 | − 1.61 | 0.24 | |
| KPS ≥ 70 (yes/no) | − 0.291 | < 0.0001 | − 30.51 | − 11.83 | |
| Gender | 0.120 | 0.061 | − 0.34 | 14.99 | |
| Nausea | Age ≥ 65 (yes/no) | − 0.060 | 0.388 | − 7.19 | 2.81 |
| Time since diagnosis | 0.014 | 0.840 | − 0.50 | 0.61 | |
| KPS ≥ 70 (yes/no) | − 0.021 | 0.757 | − 6.49 | 4.73 | |
| Gender | 0.156 | 0.021 | 0.84 | 10.01 | |
| Pain | Age ≥ 65 (yes/no) | 0.028 | 0.690 | − 6.93 | 10.45 |
| Time since diagnosis | 0.082 | 0.226 | − 0.37 | 1.56 | |
| KPS ≥ 70 (yes/no) | − 0.133 | 0.053 | − 19.38 | 0.120 | |
| Gender | 0.098 | 0.143 | − 2.03 | 13.92 | |
| Dyspnea | Age ≥ 65 (yes/no) | 0.087 | 0.212 | − 3.16 | 14.15 |
| Time since diagnosis | − 0.044 | 0.519 | − 1.28 | 0.65 | |
| KPS ≥ 70 (yes/no) | − 0.134 | 0.050 | − 19.39 | 0.02 | |
| Gender | 0.029 | 0.669 | − 6.23 | 9.69 | |
| Insomnia | Age ≥ 65 (yes/no) | − 0.125 | 0.074 | − 18.96 | 0.88 |
| Time since diagnosis | − 0.019 | 0.785 | − 1.25 | 0.95 | |
| KPS ≥ 70 (yes/no) | − 0.077 | 0.264 | − 17.44 | 4.80 | |
| Gender | 0.123 | 0.069 | − 0.65 | 17.59 | |
| Appetite loss | Age ≥ 65 (yes/no) | − 0.114 | 0.093 | − 16.87 | 1.31 |
| Time since diagnosis | − 0.130 | 0.053 | − 2.01 | 0.01 | |
| KPS ≥ 70 (yes/no) | − 0.210 | 0.002 | − 26.47 | − 6.08 | |
| Gender | 0.114 | 0.082 | − 0.95 | 15.73 | |
| Constipation | Age ≥ 65 (yes/no) | 0.022 | 0.754 | − 7.29 | 10.04 |
| Time since diagnosis | − 0.006 | 0.935 | − 1.02 | 0.94 | |
| KPS ≥ 70 (yes/no) | − 0.092 | 0.185 | − 16.35 | 3.17 | |
| Gender | 0.106 | 0.117 | − 1.61 | 14.35 | |
| Diarrhea | Age ≥ 65 (yes/no) | − 0.074 | 0.296 | − 9.41 | 2.88 |
| Time since diagnosis | − 0.058 | 0.399 | − 0.99 | 0.40 | |
| KPS ≥ 70 (yes/no) | − 0.065 | 0.349 | − 10.29 | 3.65 | |
| Gender | 0.011 | 0.868 | − 5.17 | 6.13 | |
| Financial difficulties | Age ≥ 65 (yes/no) | − 0.257 | < 0.0001 | − 29.95 | − 9.36 |
| Time since diagnosis | − 0.055 | 0.416 | − 1.64 | 0.68 | |
| KPS ≥ 70 (yes/no) | − 0.140 | 0.038 | − 23.91 | − 0.66 | |
| Gender | − 0.040 | 0.542 | − 12.42 | 6.55 | |
| GHS | Age ≥ 65 (yes/no) | − 0.125 | 0.058 | − 12.28 | 0.202 |
| Time since diagnosis | 0.003 | 0.960 | − 0.69 | 0.72 | |
| KPS ≥ 70 (yes/no) | 0.327 | < 0.0001 | 11.07 | 25.19 | |
| Gender | − 0.022 | 0.726 | − 6.78 | 4.73 | |
| Future uncertainty | Age ≥ 65 (yes/no) | − 0.072 | 0.287 | − 12.95 | 3.85 |
| Time since diagnosis | − 0.162 | 0.015 | − 2.07 | − 0.22 | |
| KPS ≥ 70 (yes/no) | − 0.238 | < 0.0001 | − 26.59 | − 7.68 | |
| Gender | 0.018 | 0.780 | − 6.60 | 8.78 | |
| Visual disorder | Age ≥ 65 (yes/no) | 0.149 | 0.028 | 0.77 | 13.48 |
| Time since diagnosis | − 0.048 | 0.465 | − 0.96 | 0.44 | |
| KPS ≥ 70 (yes/no) | − 0.221 | 0.001 | − 19.30 | − 4.94 | |
| Gender | 0.058 | 0.373 | − 3.18 | 8.45 | |
| Motor dysfunction | Age ≥ 65 (yes/no) | 0.059 | 0.335 | − 3.74 | 10.95 |
| Time since diagnosis | 0.004 | 0.943 | − 0.78 | 0.84 | |
| KPS ≥ 70 (yes/no) | − 0.493 | < 0.0001 | − 42.60 | − 26.13 | |
| Gender | 0.046 | 0.435 | − 4.07 | 9.41 | |
| Communication deficit | Age ≥ 65 (yes/no) | − 0.001 | 0.990 | − 8.88 | 8.76 |
| Time since diagnosis | 0.012 | 0.858 | − 0.89 | 1.06 | |
| KPS ≥ 70 (yes/no) | − 0.356 | < 0.0001 | − 37.21 | − 17.45 | |
| Gender | 0.000 | 0.999 | − 8.08 | 8.07 | |
| Headache | Age ≥ 65 (yes/no) | − 0.082 | 0.238 | − 15.76 | 3.94 |
| Time since diagnosis | 0.045 | 0.508 | − 0.72 | 1.45 | |
| KPS ≥ 70 (yes/no) | − 0.021 | 0.760 | − 12.77 | 9.33 | |
| Gender | 0.163 | 0.015 | 2.17 | 20.22 | |
| Seizures | Age ≥ 65 (yes/no) | − 0.151 | 0.030 | − 14.52 | − 0.75 |
| Time since diagnosis | 0.021 | 0.755 | − 0.63 | 0.87 | |
| KPS ≥ 70 (yes/no) | − 0.205 | 0.003 | − 19.36 | − 4.01 | |
| Gender | − 0.040 | 0.545 | − 8.22 | 4.36 | |
| Drowsiness | Age ≥ 65 (yes/no) | 0.060 | 0.378 | − 5.12 | 13.42 |
| Time since diagnosis | 0.020 | 0.761 | − 0.87 | 1.18 | |
| KPS ≥ 70 (yes/no) | − 0.255 | < 0.0001 | − 30.39 | − 9.60 | |
| Gender | 0.012 | 0.850 | − 7.68 | 9.32 | |
| Itchy skin | Age ≥ 65 (yes/no) | 0.093 | 0.185 | − 2.75 | 14.11 |
| Time since diagnosis | 0.023 | 0.740 | − 0.78 | 1.10 | |
| KPS ≥ 70 (yes/no) | − 0.111 | 0.109 | − 17.17 | 1.73 | |
| Gender | 0.079 | 0.242 | − 3.14 | 12.35 | |
| Hair loss | Age ≥ 65 (yes/no) | 0.020 | 0.768 | − 7.85 | 10.61 |
| Time since diagnosis | 0.070 | 0.290 | − 0.47 | 1.56 | |
| KPS ≥ 70 (yes/no) | − 0.042 | 0.535 | − 13.69 | 7.13 | |
| Gender | 0.291 | < 0.0001 | 20.71 | 27.64 | |
| Weakness of legs | Age ≥ 65 (yes/no) | 0.062 | 0.360 | − 5.23 | 14.33 |
| Time since diagnosis | − 0.053 | 0.426 | − 1.51 | 0.64 | |
| KPS ≥ 70 (yes/no) | − 0.307 | < 0.0001 | − 36.83 | − 14.88 | |
| Gender | 0.038 | 0.557 | − 6.25 | 11.56 | |
| Bladder control | Age ≥ 65 (yes/no) | 0.129 | 0.062 | − 0.43 | 17.32 |
| Time since diagnosis | 0.032 | 0.638 | − 0.74 | 1.21 | |
| KPS ≥ 70 (yes/no) | − 0.210 | 0.002 | − 25.75 | − 5.74 | |
| Gender | − 0.013 | 0.841 | − 8.95 | 7.30 |