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. 2020 Oct 9;10:16891. doi: 10.1038/s41598-020-70861-x

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Acquired drug resistant prevalence and the most representative mutations in the study pretreated population from the Madrid Cohort of HIV-1 infected children and adolescents. (A) ADR prevalence according to drug class in 167 pretreated patients with pol sequence or resistance data. (B) ADR prevalence over 5% in 167 pretreated patients. Triple-class: ADR to NNRTI + NRTI + PI. ADR to NNRTI + PI was not found. Error bars indicate exact hybrid Wilson/Brown 95% CIs. Statistical differences: ****p < 0.0001; **p < 0.01; *p < 0.05 Chi-square test. Results were calculated in 49 PR and 45 RT sequences or resistance profiles from non-transferred patients and in 110 PR and 103 RT sequences or resistance profiles from transferred individuals at sampling. ADR acquired HIV drug resistance mutations, NTP non-transferred patients, TP transferred patients.