Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Oct 9;3:564. doi: 10.1038/s42003-020-01278-5

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 3 — a, b Sera from primed and non-primed ferrets was tested for antibody responses against A/California/07/2009 (H1N1) and A/Singapore/1/57 (H2N2) before H1N1-priming (day 0), before H2N2 infection (day 28) and 2 weeks after H2N2 infection (day 42). Bars depict mean ± SD. a Hemagglutination-inhibition (HAI) titers against H1N1 and H2N2. b Virus neutralization titer against H2N2. c–e IFNγ-responses by ELISpot after ex vivo stimulation of PBMCs obtained 28 days after H1N1-priming. Responses are corrected for background signals (minus medium stimulation). c Responses against H1N1, H2N2, A/Switzerland/97/2013 (H3N2), and mumps virus. d Responses of H1N1-primed animals to peptide pools spanning the internal proteins of H2N2 and the control HIV gag protein. Non-primed and placebo animals were negative for all peptide pools tested but were left out for visualization purposes. e For each ferret shown in d, relative responses against the different influenza proteins was calculated. Boxplots depict the 25, 50, and 75% quantile where the upper and lower whiskers extend to the smallest and largest value respectively within 1.5* the inter quartile ranges. In all plots n = 6. * indicates significant differences (p < 0.05) between non-primed and H1N1-primed groups after correction for multiple testing.