. 2020 Feb 28;28(11):5299–5306. doi: 10.1007/s00520-020-05333-z

Table 4.

Univariate and multivariate analysis for factors effecting early initiation (< 4 weeks) of AC

Variables	Univariate HR p value	Multivariate HR p value
Age
≥ 75 < 75	1 (Ref) 1.176 0.625	NS
Socioeconomic status
Low to moderate income High income	1 (Ref) 2.389 < 0.001	1 (Ref) 1.880 0.012
Education
Illiterate/primary school High school/undergraduate	1 (Ref) 1.318 0.294	NS
Cancer TYPE
Rectal Colon	1 (Ref) 1.332 0.236	NS
Serum CEA
Elevated Normal	1 (Ref) 1.475 0.156	NS
Serum NLR
≥ 2.4 < 2.4	1 (Ref) 1.366 0.221	NS
Complication
Yes No	1 (Ref) 3.807 0.009	NS
HADS-anxiety
Yes (≥ 11) No (< 11)	1 (Ref) 5.081 0.020	1 (Ref) 3.881 0.009
HADS-depression
Yes (≥ 11) No (< 11)	1 (Ref) 5.866 0.079	NS
SCNS-SF34 score
High need Low need	1 (Ref) 4.577 < 0.001	1 (Ref) 4.162 < 0.001

Variables

Univariate HR p value

Multivariate HR p value

Age

≥ 75

< 75

1 (Ref)

1.176 0.625

Socioeconomic status

Low to moderate income

High income

1 (Ref)

2.389 < 0.001

1 (Ref)

1.880 0.012

Education

Illiterate/primary school High school/undergraduate

1 (Ref)

1.318 0.294

Cancer TYPE

Rectal

Colon

1 (Ref)

1.332 0.236

Serum CEA

Elevated

Normal

1 (Ref)

1.475 0.156

Serum NLR

≥ 2.4

< 2.4

1 (Ref)

1.366 0.221

Complication

Yes

1 (Ref)

3.807 0.009

HADS-anxiety

Yes (≥ 11)

No (< 11)

1 (Ref)

5.081 0.020

1 (Ref)

3.881 0.009

HADS-depression

Yes (≥ 11)

No (< 11)

1 (Ref)

5.866 0.079

SCNS-SF34 score

High need

Low need

1 (Ref)

4.577 < 0.001

1 (Ref)

4.162 < 0.001

HR, hazard ratio; CEA, carcinoembryonic antigen; AC, adjuvant chemotherapy; NLR, neutrophil to lymphocyte ratio; NS, not significant