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. 2020 Oct 9;11:5099. doi: 10.1038/s41467-020-18865-z

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 9 — a Blood lactate concentration of non-heat sensitive (n = 5) and heat-sensitive (n = 10) MHS patients carrying RYR1 variants. b, c Representative immunoblots (b) and relative protein levels (c) for the mitochondrial uncoupling protein (UCP1) in differentiation assay of immortalized human preadipocytes from stromal–vascular fraction of brown adipose tissue treated with vehicle control and different dose of ectopic lactate (n = 5 each). d Proposed model of an adaptive thermogenesis enhanced feed-forward cycle of heat-induced heat response in susceptible patients. P values are indicated as Welch’s t test (a, c). All statistical tests are two-sided. Data are represented as mean ± standard deviation (a) and mean ± standard error of the mean (c). Relative protein levels are determined as levels normalized to the level of vehicle-treated controls (c). Source data are provided as a source data file.