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. 2020 Oct 9;11:5114. doi: 10.1038/s41467-020-18643-x

Fig. 7. Concomitant ablation of Fgfr1, Fgfr2, and beta-catenin specifically in the DP results in premature induction of catagen.

Fig. 7

a–d HE staining of skin sections from control, dMF1/2, Ctnnb1, and tMF1/2/b mice at P16 is shown. Note the unsynchronized nature of catagen in both Ctnnb1 and tMF1/2/b mutant mice. n > 3 mice per genotype. e Tunel staining of P13 skin sections from control, dMF1/2 double mutant, Ctnnb1 mutant, and tMF1/2/b triple mutant is shown to illustrate the normal apoptosis around the DP during the premature catagen. Pcad immunostaining was also included to outline the DP. Nuclei are in blue (DAPI). n = 3 mice per genotype. f Higher magnifications of the fields surrounding the DP of Ctnnb1 and tMF1/2/b mutant follicles in e are displayed. Scale bar in (a–d), 200 μm. Scale bar in (e, f), 25 μm.