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. 2020 Sep 30;26(4):486–495. doi: 10.5056/jnm20079

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© 2020 The Korean Society of Neurogastroenterology and Motility

This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Pearson correlation analyses between brain-derived neurotrophic factor (BDNF) levels and Beck’s Depression Inventory (BDI) score changes among the 3 groups. X-axis represents BDI score changes and y-axis represents BDNF changes. As shown, there is negative correlation between the change in BDNF levels and BDI scores over 8-week supplementation period, while the correlation in probiotic group (r = –0.79, P < 0.001) is larger compared to prebiotic group (r = –0.19, P = 0.190) or placebo group (r = –0.69, P = 0.001).