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The PHF8-PKCα axis regulates PTEN destabilization by SRC activation. (A) Immunoblotting analysis of PTEN expression in shPHF8 (#1 and #2) and shPRKCA (#1 and #2) MKN28 with or without MG132 treatment. (B) Abundance of Src and pSrc (Y419) in pLKO or shPHF8 (#1 or #2) transfected with a control (ctl) or a PRKCA-expressing vector. (C) Detection of PTEN in shPRKCA (#1 and #2) cells transfected with a kinase-active Src (Y419D) or a kinase-dead Src (Y419F) vector.
