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. 2020 Sep 23;117(40):24691–24700. doi: 10.1073/pnas.2006764117

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Copyright © 2020 the Author(s). Published by PNAS.

This open access article is distributed under Creative Commons Attribution-NonCommercial-NoDerivatives License 4.0 (CC BY-NC-ND).

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Fig. 1. — A complex sarcomeric proteoform landscape. (A) Control tissue from left ventricle (LV) of nonfailing donor hearts (Ctrl, n = 16) and HCM tissues procurred via surgical septal myectomy procedure (HCM, n = 16). (B) Schematic representation of cardiac sarcomere, consisting of thin (green) and thick filaments (pink) flanked by Z-disk. (C) Sarcomeric protein interactome showing a complex network of interactions between myofilament and Z-disk proteins. (D) Representative base peak chromatograms showing separation and detection of major sarcomeric proteins by LC-MS for Ctrl and HCM tissues. (E and F) Representative deconvoluted mass spectra showing the proteoforms of (E) myofilament and (F) Z-disk proteins.