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Differential tropomyosin isoform expression in HCM. (A) Representative deconvoluted spectra showing Tpm proteoforms Tpm1.2, Tpm1.1, and pTpm1.1 proteoforms. (B) Zoom-in to baseline of deconvoluted mass spectra to show lower abundance Tpm proteoforms, Tpm2.2, Tpm3.12, and pTpm3.12. Monophosphorylation denoted by red p.
