Table 2.

Associations with AATD: Medicare

Total Medicare Cohort
Total	AATD		Non-AATD		OR	LCI	UCI	p-value
	(n)	(%)	(n)	(%)
	302	0.1%	344,226	99.9%
Age Cohorts
0–40	6	2.0%	4,189	1.2%	0.53	0.22	1.26	0.98
41–50	38	12.6%	14,925	4.3%	Reference group
51–64	108	35.8%	68,091	19.8%	0.62	0.43	0.90	0.22
≥65**	150	49.7%	257,021	74.7%	0.24	0.16	0.34	<0.0001
Male	137	45.4%	159,329	46.3%	0.97	0.77	1.22	0.78
Comorbidities
Cardiac Arrhythmias
Conduction Disorders	10	3.3%	17,594	5.1%	0.87	0.45	1.67	0.67
Cardiac Dysrhythmias	163	54.0%	190,497	55.3%	1.04	0.81	1.34	0.74
Symptoms involving Cardiovascular System	69	22.8%	58,729	17.1%	1.24	0.94	1.65	0.13
Mechanical Complication of Cardiac Device, Implant and Graft	1	0.3%	6,020	1.7%	0.28	0.04	2.15	0.22
Cardiac Device in Situ	19	6.3%	39,299	11.4%	0.66	0.37	1.19	0.17
Fitting and Adjustment of Cardiac Device	8	2.6%	18,871	5.5%	0.89	0.37	2.13	0.79
Pulmonary Circulation Disease
Acute Pulmonary Heart Disease	31	10.3%	23,166	6.7%	1.39	0.95	2.05	0.09
Chronic Pulmonary Heart Disease*	72	23.8%	65,165	18.9%	1.40	1.05	1.86	0.02
Other Diseases of Pulmonary Circulation	2	0.7%	1,672	0.5%	1.06	0.26	4.31	0.94
Liver Disease
Viral Hepatitis**	6	2.0%	8,099	2.4%	0.28	0.12	0.67	0.00
Varicose Veins of Other Sites	7	2.3%	3,643	1.1%	1.22	0.50	2.97	0.67
Acute and Subacute Necrosis of Liver	7	2.3%	3,804	1.1%	1.28	0.58	2.82	0.53
Chronic Liver Disease and Cirrhosis*	5	1.7%	457	0.1%	1.47	1.05	2.06	0.03
Liver Abscess and Sequelae of Chronic Liver Disease*	6	2.0%	8,099	2.4%	2.01	1.10	3.68	0.02
Other Disorders of Liver	7	2.3%	3,643	1.1%	0.89	0.61	1.29	0.53
Liver Transplant**	7	2.3%	3,804	1.1%	7.01	2.67	18.40	<0.0001

Notes: *p<0.05; **p<0.01.

Abbreviations: OR, odds ratio; LCI, lower confidence interval; UCI, upper confidence interval.