Table 3.

Associations with AATD: PharMetrics Plus

Total PharMetrics Plus Cohort
Total	AATD		Non-AATD		OR	LCI	UCI	p-value
	(n)	(%)	(n)	(%)
	1076	0.3%	339,183	99.7%
Age Cohorts
0–40*	101	9.4%	23,181	6.8%	1.07	0.85	1.36	0.022
41–50	236	21.9%	58,556	17.3%	Reference group
51–64**	739	68.7%	257,446	75.9%	0.70	0.61	0.82	<0.0001
Male	532	49.4%	163,385	48.2%	1.09	0.96	1.23	0.1785
Comorbidities
Cardiac Arrhythmias
Conduction Disorders	14	1.3%	4,323	1.3%	0.89	0.52	1.54	0.6824
Cardiac Dysrhythmias	204	19.0%	58,564	17.3%	0.93	0.79	1.10	0.3823
Symptoms involving Cardiovascular System**	217	20.2%	39,517	11.7%	1.72	1.47	2.02	<0.0001
Mechanical Complication of Cardiac Device, Implant and Graft	1	0.1%	1,058	0.3%	0.37	0.05	2.79	0.3325
Cardiac Device in Situ	17	1.6%	7,878	2.3%	0.68	0.38	1.20	0.1805
Fitting and Adjustment of Cardiac Device	9	0.8%	4,391	1.3%	0.77	0.35	1.67	0.5027
Pulmonary Circulation Disease
Acute Pulmonary Heart Disease	51	4.7%	12,397	3.7%	0.87	0.65	1.18	0.3704
Chronic Pulmonary Heart Disease**	159	14.8%	22,941	6.8%	2.30	1.92	2.76	<0.0001
Other Diseases of Pulmonary Circulation	4	0.4%	818	0.2%	0.87	0.32	2.34	0.7773
Liver Disease
Viral Hepatitis*	21	2.0%	8,233	2.4%	0.55	0.35	0.88	0.0115
Varicose Veins of Other Sites**	23	2.1%	2,181	0.6%	2.31	1.30	4.11	0.0042
Acute and Subacute Necrosis of Liver	2	0.2%	1,265	0.4%	0.26	0.06	1.06	0.0611
Chronic Liver Disease and Cirrhosis**	163	15.1%	36,482	10.8%	1.28	1.07	1.54	0.0078
Liver Abscess and Sequelae of Chronic Liver Disease	31	2.9%	4,723	1.4%	0.98	0.59	1.62	0.9248
Other Disorders of Liver	94	8.7%	23,846	7.0%	1.03	0.82	1.30	0.8149
Liver Transplant**	12	1.1%	518	0.2%	4.22	2.19	8.13	<0.0001
Coagulopathy
Coagulopathy defects	52	4.8%	10,687	3.2%	1.16	0.86	1.57	0.3353
Purpura and other hemorrhagic events	68	6.3%	15,990	4.7%	0.94	0.72	1.24	0.6635

Notes: *p<0.05; **p<0.01.

Abbreviations: OR, odds ratio; LCI, lower confidence interval; UCI, upper confidence interval.