Table.
Characteristics of patients with normal and abnormal cardiac markers
| Characteristic | Patients with normal cardiac biomarkers (n=13) | Patients with elevated cardiac biomarkers (n=7) |
|---|---|---|
| Maternal age (y) | 33.0±4.4 | 32.0±4.5 |
| ≥35 y | 2 (15.4) | 3 (42.9) |
| Race or ethnicity | ||
| White | 5 (38.5) | 2 (28.5) |
| African American | 2 (15.4) | 0 |
| Hispanic | 6 (42.8) | 0 |
| Asian | 0 | 3 (42.8) |
| Other, unknown, or multiracial | 0 | 2 (28.5) |
| Multiparous | 9 (69.2) | 7 (100) |
| Parity of 3 or more | 3 (23.1) | 2 (28.5) |
| BMI prepregnancy (kg/m2) | 34.7±6.7 | 32.5±6.0 |
| ≥30 kg/m2 | 8 (61.5) | 5 (71.4) |
| Medical comorbidities | ||
| Hypertension | 0 | 0 |
| Diabetes | 0 | 1 (14.3) |
| Asthma | 1 (7.7) | 1 (14.3) |
| Preexisting cardiac disease | 0 | 0 |
| Pregnancy complications | ||
| Gestational diabetes | 1 (7.7) | 0 |
| Gestational hypertension or preeclampsia | 3 (23.1) | 2 (28.5) |
| COVID-19 | ||
| Gestational age at hospitalization (wk) | 33.5 (10.8) | 34.5 (4.5) (1 postpartum) |
| Reported symptoms | ||
| Fever, subjective or measured | 9 (69.2) | 6 (85.7) |
| Cough | 8 (61.5) | 6 (85.7) |
| Dyspnea | 9 (69.2) | 6 (85.7) |
| Nausea or diarrhea | 1 (7.7) | 1 (14.3) |
| Other | 0 | 1 (14.3) (abdominal pain) |
| Medications | ||
| Hydroxychloroquine | 11 (84.6) | 3 (42.8) |
| Corticosteroids | 5 (38.5) | 4 (57.1) |
| Remdesivir | 0 | 2 (28.5) |
| Interleukin inhibitors | 1 (7.7) | 3 (42.8) |
| Convalescent plasma | 0 | 1 (14.3) |
| Vital signs | ||
| Temperature, ≥100.4°F or 38.0°C | 6 (42.8) | 5 (71.4) |
| Max HR, >100 bpm | 10 (76.9) | 6 (85.7) |
| Min HR, <60 bpm | 6 (42.8) | 3 (42.8) |
| Respiratory rate, >30 bpm | 4 (30.7) | 4 (57.1) |
| Oxygen saturation (min), % | 87.8±6.2 | 84.6±10.2 |
| ≤93% | 11 (84.6) | 5 (71.4) |
| Biomarkers | ||
| BNP, >300 pg/mL | 0 | 4 (57.1) |
| hs-Trop, >6–14 ng/L | 0 | 1 (14.3) |
| Troponin T, >0.06 ng/mL | 0 | 1 (14.3) |
| Troponin I, >0.045 ng/mL | 0 | 2 (28.5) |
| Echocardiogram | 1 (7.7) | 3 (42.8) |
| Number of d admitted to hospital | 8 (11.0) | 4 (9.0) |
| Intensive care unit admission | 5 (38.5) | 6 (85.7) |
| Maternal mortality | 0 | 2 (28.5) |
Data are presented as number (percentage), median (interquartile range), or mean±standard deviation unless otherwise specified.
Reference ranges: high sensitivity cardiac troponins, <6–14 ng/L; troponin T, 0.00–0.06 ng/mL; troponin I, 0.000–0.045; BNP, <300 pg/mL.
BMI, body mass index; BNP, brain natriuretic peptide; COVID-19, coronavirus disease 2019; HR, heart rate; Max, maximum; Min, minimum.
Shetty. Myocardial injury associated with coronavirus disease 2019. Am J Obstet Gynecol 2021.