Table 4.

Cooccurrence or mutual exclusive alterations of 7 hub genes in LUAD ranked by p value.

Gene A	Gene B	p value	Log odds ratio	Association
CDH5	PECAM1	<0.001	>3	Tendency towards cooccurrence
CDH5	VWF	<0.001	>3	Tendency towards cooccurrence
VWF	PECAM1	0.007	>3	Tendency towards cooccurrence
MMP9	SPP1	0.097	2.315	Tendency towards cooccurrence

The correlation analysis of 7 hub genes showed that the relationships of gene pairs that were statistically significant (p < 0.05) all had a tendency towards cooccurrence. Log odds ratio > 0: association towards cooccurrence. Log odds ratio ≤ 0: association towards mutual exclusivity. p value < 0.05: significant association. p value: derived from Fisher Exact Test. Log odds ratio: quantifies how strongly the presence or absence of alterations in gene A is associated with the presence or absence of alterations in gene B in the selected tumors.