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Effects of repeated LPS injections and CLP on hippocampal inflammatory mediators. There were significantly increased hippocampal pNF-κB p65, IL-1β, and IL-6 levels following CLP. However, repeated LPS injections were able to prevent the increased pNF-κB p65 and IL-1β levels. Data represent mean ± SEM; n = 5/group. ∗P < 0.05 vs. sham + Veh group; #P < 0.05 vs. CLP + Veh group. LPS: lipopolysaccharide; CLP: cecal ligation and puncture; Veh: vehicle.
