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. 2020 Sep 25;22(9):e17831. doi: 10.2196/17831

Table 1.

Effect sizes regarding depressive symptoms in the meta-analysis of studies comparing computerized cognitive behavior therapy in adolescents and young adults with active treatment and passive controls at posttreatment.

Variable Ncoma Nparb Effect size Heterogeneity Gradec NNTd
g 95% CI I 2 95% CI
All studies








Active treatment controls 5 403 −0.55 −1.18 to 0.08 87.52 73 to 94 ++ 3.31

Passive controls 20 1604 0.52e 0.33 to 0.71 68.69 50 to 80 ++ 3.5


One outlier removedf 19 1558 0.46e 0.29 to 0.63 58.49 31 to 75 +++ 3.91
Studies aimed at depression








Active treatment controls 4 351 −0.70 −1.51 to 0.11 90.63 79 to 96 + 2.63

Passive controls 13 1162 0.60e 0.35 to 0.85 73.27 54 to 85 ++ 3.05


One outlier removedf 12 1116 0.51e 0.30 to 0.72 61.76 28 to 80 ++ 3.55

aNcom: number of comparisons.

bNpar: number of participants.

c+: very low quality; ++: low quality; +++: moderate quality.

dNNT: number needed to treat.

eP<.001.

fOutlier Sethi (2013) excluded.