Table 1.

Tabular representation QMEAN, Cβ, solubility and torsion obtained from SWISS model algorithm and domain location of studied SOD1 variants

Mutation	ConSurf	Nature	QM	Cβ	All atom	Solv	Tor	Mutation	ConSurf	Nature	QM	Cβ	All atom	Solv	Tor
L39V	Con.	NP	2.67	2.71	−0.89	0.38	2.15	V149G	Con.	NP	2.46	2.98	−0.85	0	2.02
G38R	Con	PB	1.77	2.45	−0.97	0.33	1.28	G148D	Con.	PA	2.53	2.7	−1.02	0.39	2.01
Q23R	Con.	PB	2.56	2.68	−0.96	0.36	2.06	N140L	Con.	NP	2.37	2.56	−1.09	0.37	1.88
Q23L	Con.	NP	2.89	2.9	−0.96	0.37	2.36	V149I	Con.	NP	2.69	2.82	−0.9	0.42	2.14
N87S	Con.	P	2.69	2.75	−0.96	0.33	2.19	T55R	Con.	PB	2.72	2.71	−0.9	0.41	2.2
N87I	Con.	NP	2.5	2.64	−0.87	0.46	1.96	S135N	Con.	P	2.55	2.73	−0.87	0.33	2.04
G42S	Con.	P	2.04	2.9	−0.92	0.38	1.45	S135T	Con.	P	2.72	2.43	−0.93	0.32	2.29
G42D	Con.	PA	2.13	2.87	−0.97	0.38	1.56	L85V	Con.	NP	2.67	2.72	−0.93	0.37	2.16
H44R	Con.	PB	2.36	2.51	−0.93	0.33	1.89	G17S	Con.	P	2.52	2.65	−1.04	0.23	2.07
G86S	Con.	P	2.01	2.79	−0.9	0.28	1.48	G17C	Con.	P	2.55	2.57	−1.07	0.21	2.13
G86R	Con.	PB	2.35	2.39	−1.06	0.32	1.92	L127S	Con.	P	2.9	3.11	−0.8	0.33	2.33
L107V	Con.	NP	2.73	2.8	−0.88	0.35	2.21	I114T	Avg.	P	2.75	2.69	−0.92	0.29	2.28
L107F	Con.	NP	2.45	2.28	−0.89	0.33	2.03	I105F	Avg.	NP	2.65	2.57	−0.94	0.27	2.21
A5V	Con.	NP	2.55	2.79	−0.92	0.23	2.07	C7T	Avg.	P	2.44	2.75	−0.9	0.27	1.95
H47R	Con.	PB	2.72	2.71	−0.91	0.24	2.26	C7F	Avg.	NP	2.43	2.41	−0.96	0.1	2.07
A5T	Con.	P	2.56	2.56	−0.97	0.24	2.13	I152T	Avg.	P	2.59	2.71	−0.88	0.34	2.08
A5S	Con.	P	2.82	2.65	−0.93	0.32	2.34	G13R	Avg.	PB	2.52	3.09	−0.87	0.59	1.84
A146T	Con.	P	2.52	2.84	−1.05	0.26	2.02	S106L	Avg.	NP	2.49	2.82	−0.98	0.36	1.96
G73S	Con.	P	2.42	2.46	−0.92	0.26	1.99	S106L	Avg.	NP	2.49	2.82	−0.98	0.36	1.96
G73C	Con.	P	2.54	2.45	−0.91	0.3	2.1	I113T	Avg.	P	2.7	2.76	−0.97	0.34	2.19
F46S	Con.	P	2.76	2.84	−0.93	0.35	2.24	I36F	Avg.	NP	2.64	2.61	−1.08	0.29	2.19
F46C	Con.	P	2.79	2.75	−0.96	0.37	2.29	F65L	Avg.	NP	2.71	2.89	−0.89	0.36	2.17
H81R	Con.	PB	2.69	2.79	−0.89	0.3	2.18	E101G	Var	NP	2.53	2.49	−1.01	−0.05	2.21
I150T	Con.	P	2.47	2.69	−0.92	0.34	1.97	L145S	Var	P	2.61	2.71	−0.86	0.32	2.12
V119L	Con.	NP	2.57	2.71	−0.88	0.35	2.06	E22K	Var	PB	2.61	2.47	−1.12	0.37	2.16
A90V	Con.	NP	2.82	2.8	−1.03	0.22	2.36	D97N	Var	P	2.67	2.71	−0.87	0.3	2.18
R116G	Con.	NP	2.82	2.59	−0.93	0.41	2.33	L145F	Var	NP	2.66	2.85	−0.91	0.36	2.12
R116C	Con.	P	2.56	2.57	−0.98	0.47	2.04	G74R	Var	PB	2.49	2.59	−0.98	0.24	2.04
L85F	Con.	NP	2.6	2.71	−0.93	0.28	2.12	D91A	Var	NP	2.52	2.99	−0.78	0.27	1.98
V88A	Con.	NP	2.57	2.68	−0.89	0.22	2.11	N20S	Var	P	2.7	2.76	−0.81	0.36	2.18
I150T	Con.	P	2.47	2.69	−0.92	0.34	1.97