Table 5.

Frequency of studied SOD1 variants based on their structural and functional annotation parameters by various bioinformatics tools

Parameter	Component(s)	Frequency
Domain location	Variable	8
	Average	11
	Conserve	49
PROVEAN phenotype	Deleterious	62
PROVEAN phenotype	Neutral	6
SIFT phenotype	Affect protein	52
SIFT phenotype	Tolerant	16
DDG iMutant stability	Decrease	63
DDG iMutant stability	Increase	5
EcoDDG stability	Destabilize	60
EcoDDG stability	Stabilize	8
Eco entropy dynamut Flexibility	Decrease	38
Eco entropy dynamut Flexibility	Increase	30
HumDiv phenotype	Benign	7
	Possibly damaging	8
	Probably damaging	53
RegulomeDB	2b + 3a	11
	4	46
	5	9