Table 6.
Frequency distribution of various structural and functional parameters among groups classified based on mutation location (conserved or variable domains) and their association by Fisher’s exact test
| Parameters | Number | Domain location | P | ||
|---|---|---|---|---|---|
| Variable | Average | Conserve | |||
| Nature of Mutation | Polar | 3 | 6 | 18 | 0.806 |
| Non Polar | 3 | 4 | 21 | ||
| Charged | 2 | 1 | 10 | ||
| PROVEAN Phenotype | Deleterious | 4 | 11 | 47 | <0.0001 |
| Neutral | 4 | 0 | 2 | ||
| PHD-SNP Phenotype | Disease | 5 | 11 | 47 | 0.002 |
| Neutral | 3 | 0 | 2 | ||
| SIFT Phenotype | Affect Protein | 0 | 8 | 44 | <0.0001 |
| Tolerant | 8 | 3 | 5 | ||
| DDG iMutant Stability | Decrease | 8 | 10 | 45 | 0.694 |
| Increase | 0 | 1 | 4 | ||
| EcoDDG Stability | Destabilize | 7 | 9 | 44 | 0.757 |
| Stabilize | 1 | 2 | 5 | ||
| EcoEntropy Dynamut Flexibility | Decrease | 4 | 5 | 29 | 0.666 |
| Increase | 4 | 6 | 20 | ||
| HumDiv Phenotype | Benign | 4 | 0 | 3 | 0.002 |
| Possibly Damaging | 1 | 2 | 5 | ||
| Probably Damaging | 3 | 9 | 41 | ||
| RegulomeDB | 2b + 3a | 1 | 2 | 8 | 0.769 |
| 4 | 6 | 8 | 32 | ||
| 5 | 0 | 1 | 8 | ||