Table 7.

Multiple regression analysis to demonstrate the association of structural and functional parameters of SOD1 variants and their correlation with ALS

Coefficients
Dependent variable: PROVEAN Score
	Unstandardized coefficients		Standardized coefficients	T	P
	B	Std. Error	beta
(Constant)	−13.98	2.891		−4.836	0
QMEAN	3.299	1.058	0.358	3.119	0.003
Dependent variable: QMEAN
(Constant)	2.921	0.065		44.757	0
PROVEAN Score	0.037	0.012	0.336	3.025	0.004
Eco DDG DynaMut	−0.156	0.063	−0.274	−2.47	0.016
Dependent variable: DDG iMutant value
(Constant)	−1.376	0.127		−10.811	0
Eco Entropy Dynamut	−0.582	0.244	−0.281	−2.382	0.02
Dependent variable: PolyPhen-2 Score
(Constant)	0.621	0.076		8.14	0
PROVEAN Score	−0.054	0.014	−0.429	−3.863	0.02