Table 3.
Univariate and multivariate analyses of OS
| Characteristic | Parameter | Univariate analysis | Multivariate analysis | ||
|---|---|---|---|---|---|
| HR(95% CI) | P | HR(95% CI) | P | ||
| Gender | Female / Male | 0.712 (0.492–1.032) | 0.073 | – | NI |
| Age (years) | <60/ ≥60 | 1.570 (1.083–2.277) | 0.017 | 1.492 (0.994–2.240) | 0.054 |
| NE(×109/L) | <7/≥7 | 1.764 (1.171–2.657) | 0.007 | 1.080 (0.620–1.883) | 0.785 |
| LY(×109/L) | <4/≥4 | 0.788 (0.250–2.482) | 0.684 | – | NI |
| HGB(g/L) | <100/≥100 | 0.869 (0.600–1.258) | 0.458 | – | NI |
| PLT(×109/L) | <300/≥300 | 1.012 (0.699–1.466) | 0.948 | – | NI |
| ALT(U/L) | <40/≥40 | 1.424 (0.894–2.270) | 0.137 | – | NI |
| AST(U/L) | <45/≥45 | 1.279 (0.825–1.983) | 0.272 | – | NI |
| ALP(U/L) | <100/≥100 | 1.171 (0.680–2.017) | 0.568 | – | NI |
| GGT(U/L) | <50/≥50 | 0.953 (0.545–1.664) | 0.867 | – | NI |
| ALB(g/L) | <35/≥35 | 0.976 (0.629–1.514) | 0.914 | – | NI |
| TBIL (mmol/L) | <20.5/≥20.5 | 1.088 (0.701–1.688) | 0.706 | – | NI |
| IBIL (mmol/L) | <15/≥15 | 1.493 (1.030–2.166) | 0.035 | 1.345 (0.895–2.021) | 0.154 |
| CRP (mg/L) | <8/≥8 | 1.189 (0.779–1.814) | 0.422 | – | NI |
|
Tumor differentiation |
high/ moderate / poor | 2.029 (1.421–2.895) | <0.001 | 1.669 (1.126–2.476) | 0.011 |
| Tumor size (cm) | <2/≥2 | 1.082 (0.837–1.397) | 0.548 | – | NI |
| Macrovascular Invision | Absent/Present | 1.998 (1.010–3.954) | 0.047 | 1.521 (0.639–3.621) | 0.344 |
| Microvascular Invision | Absent/Present | 1.592 (1.080–2.347) | 0.019 | 1.098 (0.708–1.703) | 0.678 |
| LN metastasis | Absent/Present | 1.545 (1.066–2.240) | 0.022 | 0.640 (0.276–1.487) | 0.299 |
| TNM Stage | IA/IB/IIA/IIB/III | 1.208 (1.051–1.388) | 0.008 | 1.035 (0.777–1.379) | 0.814 |
| CEA (μg/L) | <5/≥5 | 1.356 (1.030–2.289) | 0.035 | 1.172 (0.771–1.283) | 0.457 |
| CA199(U/mL) | <35/≥35 | 2.075 (1.289–3.339) | 0.003 | 1.250 (0.745–2.096) | 0.398 |
| Chemotherapy | Absent/Present | 0.816 (0.562–1.186) | 0.286 | – | NI |
| LNMS | N0/N1/N2 | 1.574 (1.199–2.067) | 0.001 | 1.786 (0.882–3.618) | 0.107 |
| PLNR | ≤0.167/>0.167 | 1.367 (0.870–2.150) | 0.176 | – | NI |
| NLR | ≤3.32/>3.32 | 1.599 (1.104–2.317) | 0.013 | 0.820 (0.399–1.683) | 0.588 |
| dNLR | ≤1.94/>1.94 | 1.451 (1.002–2.101) | 0.049 | 0.894 (0.478–1.673) | 0.726 |
| PLR | ≤99.02/>99.02 | 1.389 (0.676–2.853) | 0.371 | – | NI |
| PI | 0 / 1 / 2 | 1.216 (0.906–1.633) | 0.193 | – | NI |
| PNI | 0 / 1 | 1.063 (0.693–1.632) | 0.778 | – | NI |
| mGPS | 0/1/2 | 0.996 (0.784–1.264) | 0.971 | – | NI |
| NLR-PI | 1 / 2 / 3 | 1.570 (1.192–2.068) | 0.001 | 1.684 (1.015–2.796) | 0.044 |