Table 4.

Clinical outcome of women versus men with nr-axSpA after 1 year of treatment with a first TNF inhibitor

Type of analysis	Outcome	Unadjusted analyses						Adjusted analyses#
		N	Women %	Men %	OR	95% CI	p	N	OR	95% CI	p
Response/tolerance*	ASAS20	99	27	57	0.28	0.11; 0.68	0.002	93	0.16	0.04; 0.50	0.003
	ASAS40	99	17	38	0.34	0.12; 0.93	0.02	93	0.19	0.05; 0.62	0.009
	BASDAI50	98	23	50	0.30	0.11; 0.77	0.007	93	0.19	0.05; 0.58	0.005
	ASDAS improvement ≥ 1.1	84	28	58	0.29	0.10; 0.78	0.008	82	0.26	0.08; 0.75	0.02
	ASDAS < 2.1	93	27	49	0.39	0.15; 1.00	0.03	86	0.18	0.04; 0.65	0.01
	ASDAS improvement ≥ 2	84	4	26	0.13	0.01; 0.68	0.005	82	0.04	0.00; 0.27	0.003
	ASDAS < 1.3	93	8	29	0.23	0.05; 0.82	0.01	86	0.07	0.01; 0.39	0.005
Completer**	ASAS20	68	45	73	0.31	0.10; 0.94	0.03	66	0.15	0.03; 0.60	0.01
	ASAS40	68	29	49	0.44	0.14; 1.31	0.14	66	0.25	0.06; 0.91	0.04
	BASDAI50	67	39	64	0.36	0.12; 1.07	0.05	66	0.20	0.05; 0.75	0.02
	ASDAS improvement ≥ 1.1	61	46	67	0.44	0.14; 1.38	0.13	60	0.36	0.09; 1.29	0.13
	ASDAS < 2.1	67	43	59	0.53	0.18; 1.54	0.22	63	0.28	0.06; 1.12	0.08
	ASDAS improvement ≥ 2	61	7	30	0.18	0.02; 0.98	0.03	60	0.05	0.00; 0.38	0.01
	ASDAS < 1.3	67	13	35	0.29	0.06; 1.11	0.05	63	0.08	0.01; 0.47	0.01

*Response in patients with available outcome at 1 year, patients having discontinued the first TNFi in the meantime being considered non-responders. **Response in patients still on their first TNFi at 1 year. Patients with co-morbid fibromyalgia were excluded from these analyses. ^#Adjustment for diagnostic delay, MASES, BASDAI and BMI. ASAS20 and ASAS40 20% and 40% improvement according to the ASAS criteria, respectively; ASDAS Ankylosing Spondylitis Disease Activity Score; BASDAI50 50% improvement in the BASDAI; nr-axSpA nonradiographic axial spondyloarthritis; TNF tumor necrosis factor