Table 1.
Concentrations of bone turnover markers in patients and controls. Data are expressed as mean (standard deviation) or median (interquartile ranges)
| Dose A (n = 10) 20 mg/10 mg |
Dose B (n = 10) 10 mg/10 mg |
Dose C (n = 10) 10 mg/5 mg |
Controls (n = 10) | |
|---|---|---|---|---|
| PINP (μg/l) | 54.9 (36.4–139.5) | 71.6 (42.9–126.7) | 102.4 (54.9–166.1) | 45.65 (37.8–30.2 |
| OC[1–49] (μg/l) | 21.9 (19.1–42.3) | 26.3 (20.5–39.3) | 34.2 (23.7–43.4) | 18.6 (15.7–30.2) |
| Bone ALP (μg/l) | 16.5 (10.6) | 15.5 (7.9) | 14.4 (7.6) | 12.1 (3.5) |
| CTX-I (μg/l) | 0.51 (0.29–0.96) | 0.47 (0.26–0.64) | 0.58 (0.29–0.84) | 0.32 (0.27–0.56) |
| TRACP5b (IU/l) | 2.92 (2.27–3.76) | 2.69 (2.27–3.53) | 2.76 (2.07–3.09) | 2.79 (2.64–2.97) |
| PINP:CTX-I ratio | 137 (43.5) | 181 (79.3) | 208 (56) | 136 (49.2) |
OC [1–49] = osteocalcin, PINP Procollagen type 1 peptide, Bone ALP Bone alkaline phosphatase, CTX-I C terminal cross-linking telopeptide, TRACP5b Tartrate resistant acid phosphatase 5b