Table 2.
Association of circulating serum cortisone (AUC) and total cortisol (AUC) with bone turnover markers in patients receiving hydrocortisone
| All patients on HC Spearman Correlation (r) |
Cortisone (AUC) r value, (p value) |
Cortisol (AUC) r value, (p value) |
|---|---|---|
| Bone Formation | ||
| OC[1–49] (μg/l) | −0.42, (p = 0.02)* | − 0.57, (p = 0.002)* |
| PINP (μg/l) | −0.49, (p = 0.01)* | −0.36, (p = 0.0689) |
| Bone ALP (μg/l) | 0.05, (p = 0.82) | −0.06, (p = 0.78) |
| Bone Resorption | ||
| CTX-I (μg/l) | −0.34, (p = 0.08) | −0.5, (p = 0.008)* |
| TRACP5b (IU/l) | − 0.18, (p = 0.38) | −0.2323, (p = 0.24) |
| PINP: CTX-I ratio | − 0.39, (p = 0.04)* | −0.4756, (p = 0.01)* |
HC Hydrocortisone, AUC Area under curve, OC [1–49] = osteocalcin, PINP Procollagen type 1 peptide, Bone ALP Bone alkaline phosphatase, CTX-I C terminal cross-linking telopeptide, TRACP5b Tartrate resistant acid phosphatase 5b
*p < 0.05