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Cumulative pack-years of regular smoking prior to pSS diagnosis date, stratified by HLA haplotype. Error barks demark 95% CIs. HLA, human leucocyte antigen; pSS, primary Sjögren’s syndrome. *n=155 cases, n=515 controls; †n=133 cases, n=554 controls; ‡n=119 cases, n=782 controls.
