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. Author manuscript; available in PMC: 2021 May 1.
Published in final edited form as: Toxicol Mech Methods. 2020 Mar 30;31(4):272–287. doi: 10.1080/15376516.2020.1736702

Figure 9. Br2-exposed pregnant mice exhibit diminished cardiac function at E18.5.

Figure 9.

Non-pregnant and pregnant (E14.5) mice were exposed to air or 600ppm Br2 for 30 minutes, returned to room air, then administered tadalafil (TAD) or vehicle. A) Representative echosonography LV and RV traces at E18.5 of pregnant mice exposed to air or Br2 with demarcation of ventricular sizes. HR = Heart rate, A = Area, A;s = Area systole, A;d = Area diastole, FAC = Fractional area change. B) Cardiac output (LV) determined by echosonography was decreased in Br2-exposed pregnant mice, which increased following administration of tadalafil; ANOVA: n=6–8. C) Ejection fraction (LV) was unchanged in all groups; ANOVA. D) LV end-systolic volume was similar in all groups. E) However, LV end-diastolic volume was diminished in Br2-exposed pregnant mice; n=6–8; ANOVA. All data are means±S.E.M.