Akt1/Akt2 |
Whole Body |
Mice |
Muscle and body mass loss concurrent with reduction in TBC1D1 |
Jaiswal et al. (2019) |
Akt1 |
Whole Body |
Mice |
Deletion in Akt2 null mice, resulted in severe hyperglycemia |
Lu et al. (2012) |
Akt1 |
Skeletal Muscle |
Mice |
Increased expression of two autophagic genes (Bnip3 and garabap1) |
Reynolds et al. (2012) |
Akt1 |
Whole Body |
Mice |
Weighed significantly less and had 15% less lean mass than wild type |
Goncalves et al. (2010) |
Akt1 |
Skeletal Muscle |
Mice |
Significant decrease in mass compared to wild type in the following muscles: extensor digitorum longus (EDL), gastrocnemius, anterior |
Goncalves et al. (2010) |
Akt2 |
BAT |
Mice |
Targeted adipocyte lineages generated smaller adipocytes that correlated with the appearance of tissue atrophy. Non‐targeted lineages on the other hand showed hypertrophy. Essentially, a redistribution of fat |
Sanchez‐Gurmaches et al. (2019) |
Akt2 |
Whole Body |
Mice |
Mildly diabetic |
Lu et al. (2012) |
Akt2 |
Whole Body |
Mice |
Weighed significantly less and had a 44% decrease in fat mass compared to wild type |
Goncalves et al. (2010) |
Akt2 |
Skeletal Muscle |
Mice |
Decrease in the mass compared to WT in gastrocnemius and EDL, but a 21% increase in soleus mass. |
Goncalves et al. (2010) |
Akt2 |
Hepatic |
Mice |
Decreased liver weight, de novo lipogenesis, and triglyceride levels; Inhibition of steatosis |
Leavens et al. (2009) |