Table 4. Comparison between molecular and serological methods for detecting COVID-19 virus.
| Molecular methods | Serological methods | ||||
|---|---|---|---|---|---|
| Technique based | rRT-PCR | Isothermal amplification | CRISPR-Cas12 | LFA | ELISA |
| Sample | RNA | RNA | RNA | Ag or Ab | Ag or Ab |
| Accuracy | High | High/Moderate | High | Low | Moderate |
| Time* | Hours | Minutes | Minutes | Minutes | Hours |
| Professional skills need | Yes | Yes | YES/No | No | Yes |
| POCT | No | Yes/No | Yes/No | Yes | No |
| Availability | Limited | Limited | Limited | Available | Available |
| Cost | Very high | High | Average | Low | Average |
| High throughput | Yes | No | No | No | Yes |
Note:
Time that is required for running the test without preparation time.