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. 2020 Oct 7;8:e10180. doi: 10.7717/peerj.10180

Table 4. Comparison between molecular and serological methods for detecting COVID-19 virus.

Molecular methods Serological methods
Technique based rRT-PCR Isothermal amplification CRISPR-Cas12 LFA ELISA
Sample RNA RNA RNA Ag or Ab Ag or Ab
Accuracy High High/Moderate High Low Moderate
Time* Hours Minutes Minutes Minutes Hours
Professional skills need Yes Yes YES/No No Yes
POCT No Yes/No Yes/No Yes No
Availability Limited Limited Limited Available Available
Cost Very high High Average Low Average
High throughput Yes No No No Yes

Note:

*

Time that is required for running the test without preparation time.