Table 3.
Performance summary of the FilmArray Pneumonia plus panel compared to culture as the reference standard.
| Target | Cult 1 FA 1 T Pos |
Cult 1 FA 0 F Neg |
Cult 0 FA 1 F Pos |
Cult 0 FA 0 T Neg |
FA Sens | 95% CI | FA Spec | 95% CI | FA PPV | 95% CI | FA NPV | 95% CI |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Bacteria | (n) | (n) | (n) | (n) | (%) | (%) | (%) | (%) | (%) | (%) | (%) | (%) |
| Acinetobacter baumannii complex | 12 | 1 | 6 | 40 | 92.3 | 64.0–99.8 | 87.0 | 73.7–95.1 | 66.7 | 48.3–81.1 | 97.6 | 85.8–99.6 |
| Enterobacter cloacae complex | 1 | 0 | 6 | 52 | 100.0 | 2.5–100.0 | 89.7 | 78.8–96.1 | 14.3 | 7.2–26.2 | 100.0 | |
| Escherichia coli | 4 | 0 | 4 | 51 | 100.0 | 39.8–100.0 | 92.7 | 82.4–98.0 | 50.0 | 28.0–72.0 | 100.0 | |
| Haemophilus influenzae | 2 | 0 | 6 | 51 | 100.0 | 15.8–100.0 | 89.5 | 78.5–96.0 | 25.0 | 13.5–41.5 | 100.0 | |
| Klebsiella aerogenes | 1 | 1 | 0 | 57 | 50.0 | 1.3–98.7 | 100.0 | 93.7–100.0 | 100.0 | 98.3 | 93.4–99.6 | |
| Klebsiella oxytoca | 1 | 0 | 1 | 57 | 100.0 | 2.5–100.0 | 98.3 | 90.8–100.0 | 50.0 | 12.5–87.5 | 100.0 | |
| Klebsiella pneumoniae group | 7 | 1 | 8 | 43 | 87.5 | 47.3–99.7 | 84.3 | 71.4–93.0 | 46.7 | 30.5–63.5 | 46.7 | 30.5–63.5 |
| Moraxella catarrhalis | 0 | 0 | 2 | 57 | 96.6 | 88.3–99.6 | 0.0 | 100.0 | ||||
| Proteus species | 0 | 0 | 5 | 54 | 91.5 | 81.3–97.2 | 0.0 | 100.0 | ||||
| Pseudomonas aeruginosa | 9 | 0 | 1 | 49 | 100.0 | 66.4–100.0 | 98.0 | 89.4–100.0 | 90.0 | 56.4–98.4 | 100.0 | |
| Serratia marcescens | 3 | 0 | 2 | 54 | 100.0 | 29.2–100.0 | 96.4 | 87.7–99.6 | 60.0 | 27.8–85.4 | 100.0 | |
| Staphylococcus aureus | 6 | 0 | 6 | 47 | 100.0 | 54.1–100.0 | 88.7 | 77.0–95.7 | 50.0 | 32.0–68.0 | 100.0 | |
| Streptococcus agalactiae | 0 | 0 | 1 | 58 | 98.3 | 90.9–100.0 | 0.0 | 100.0 | ||||
| Streptococcus pneumoniae | 0 | 1 | 3 | 55 | 0.0 | 0.0–97.5 | 94.8 | 85.6–98.9 | 0.0 | 98.2 | 98.1–98.3 | |
| Streptococcus pyogenes | 0 | 0 | 1 | 58 | 98.3 | 90.9–100.0 | 0.0 | 100.0 | ||||
| Bacteria cumulative | 46 | 4 | 52 | 783 | 92.0 | 80.8–97.8 | 93.8 | 91.9–95.3 | 46.9 | 40.2–53.8 | 99.5 | 98.7–99.8 |
| T Pos | F Neg | F Pos | T Neg | PPA | 95% CI | NPA | 95% CI | |||||
| Antibiotic Resistance Genes | (n) | (n) | (n) | (n) | (%) | (%) | (%) | (%) | ||||
| CTX-M | 5 | 0 | 2 | 52 | 100.0 | 47.8–100.0 | 96.3 | 87.3–99.5 | ||||
| IMP | 0 | 0 | 0 | 59 | 100.0 | 93.9–100.0 | ||||||
| KPC | 0 | 0 | 0 | 59 | 100.0 | 93.9–100.0 | ||||||
| mecA/C and MREJ | 1 | 0 | 0 | 58 | 100.0 | 2.5–100.0 | 100.0 | 93.8–100.0 | ||||
| NDM | 7 | 0 | 1 | 51 | 100.0 | 59.0–100.0 | 98.1 | 89.7–100.0 | ||||
| OXA-48-like | 4 | 0 | 3 | 52 | 100.0 | 39.8–100.0 | 94.5 | 84.9–98.9 | ||||
| VIM | 1 | 0 | 0 | 58 | 100.0 | 2.5–100.0 | 100.0 | 93.8–100.0 | ||||
| ABR genes cumulative | 18 | 0 | 6 | 389 | 100.0 | 81.5–100.0 | 98.5 | 96.7–99.4 | ||||
Key: Cult = Culture, FA = FilmArray Pneumonia plus panel, T Pos = True positive, F Neg =False negative, F Pos = False positive, T Neg = True negative, Sens = Sensitivity, CI = Confidence interval.
Spec = Specificity, PPV = Positive predictive value, NPV = Negative predictive value, ABR = Antibiotic resistance, PPA = Positive percent agreement, NPA = Negative percent agreement.