Fig. 2.

HCQ suppressed the development of CIA by restraining DC migration and maturation in vivo. (A) In LNs, the percentage of DCs including pDCs and mDCs increased in CIA group when compared to healthy control, and both of which were down-regulated after HCQ treatment (n = 6). (B, C) In contrast to healthy control, the migration ability of peripheralblood DCs and maturation of LN DCs were enhanced in CIA model, while HCQ repress the change by inhibiting the expression of CCR7, L-selectin, CCL21 and decreasing the level of CD40, CD80, CD86 and MHC II (n = 6). ^#P < 0.05, ^##P < 0.01: CIA model vs healthy control mice. * P < 0.05, ** P < 0.01: HCQ-treated mice vs vehicle-treated mice.