Table 2.

Summary of animal and human laboratory research examining lorcaserin effectiveness to attenuate opioid self-administration.

Species	Procedure(s)	Dependent measure(s)	Lorcaserin dose(s)/route	Treatment regimen	Results	Interpreted as effective for OUD (Yes/No)	Ref.
Preclinical studies
Male Sprague-Dawley rats	Oxycodone SA (FR) Cue reinstatement	Rates of responding	0.25–1 mg/kg, SC	Acute pretreatment	Decreased oxycodone SA Decreased cue reinstatement	Yes	[76]
Male Sprague-Dawley rats	Remifentanil-vs.-food choice (FR)	% remifentanil choice Rates of responding	0.1–3 mg/kg, IP	Acute pretreatment	No effect on remifentanil choice Decreased rates of responding	No	[64]
Male rhesus monkeys	Heroin SA (FR) Food-maintained responding (FR)	Rates of responding	0.32–1 mg/kg, IM	Acute and repeated (>7 days) treatment	Acute decreased heroin SA Repeated decreased both consumption and demand for small, but not large, heroin dose Acute or repeated did not decrease food-maintained responding	Yes	[77]
Female and male rhesus monkeys	Heroin + cue reinstatement	Rates of responding	0.1–1 mg/kg, SC	Acute pretreatment	Decreased heroin + cue reinstatement	Yes	[74]
Female and male rhesus monkeys	Heroin-vs.-food choice (FR)	% heroin choice Rates of responding	0.032–0.32 mg/kg/h, IV	Repeated 7-day treatment	Increased heroin choice No effect on rate	No	[78]
Human laboratory studies
Humans	Oxycodone-vs.-money choice (PR) Subjective effects	Reinforcers earned Score	10 mg twice a day, PO	Repeated 14-day treatment	No effect on oxycodone choice Increased “Want” heroin	No	[79]

SA self-administration, FR fixed-ratio schedule of reinforcement, PR progressive-ratio schedule of reinforcement.