Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Oct 9;11(10):836. doi: 10.1038/s41419-020-03049-w

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 1 — a m⁶A levels of total RNA derived from 12 pairs of cancerous and noncancerous tissues. b Differential expression (gastric cancer vs. normal tissue) of the m⁶A regulators in the TCGA-STAD database. The colors indicate the functional subgroups of the proteins. c Expression of METTL3 mRNA in 12 pairs of cancerous and noncancerous tissues. d Correlation between METTL3 mRNA levels (y-axis) and percentage of m⁶A content in total RNA (x-axis) in our clinical cohorts (n = 24). e Genetic changes of METTL3 in gastric cohorts from online databases. Original data were extracted from cBioPortal. f Representative IHC staining of METTL3 in GC tissues (100×). One representative sample of staining intensity (-), (+), (++), and (+++) were shown. Scale bars represent 50 μm. g Clinicopathologic features of patients with METTL3-low (n = 36) and high tumors (n = 51). h, i Kaplan–Meier plots of RFS (n = 58) and OS (n = 80) of patients with METTL3-low and high tumors according to IHC staining intensity. Data were derived from a gastric cancer cohort followed-up by us. j, k Kaplan–Meier plots of RFS (n = 641) and OS (n = 876) of patients with METTL3-low and high tumors according to mRNA levels. Data were interrogated from the GEO datasets GSE14210, GSE15459, GSE22377, GSE29272, GSE38749, GSE51105, and GSE62254 with the probe 209265_s_at. Data are presented as mean ± SD. *P < 0.05; **P < 0.01.