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. 2020 Oct 9;11(10):836. doi: 10.1038/s41419-020-03049-w

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — a, b Wound-healing assays of METTL3-reducing (shM3) HGC-27, METTL3-overexpressing (OE) MKN-45, and AGS, and their corresponding control (shCTL and EV) cells. c, d Migration and invasion assays of METTL3-reducing HGC-27 cells. e, f Migration and invasion assays of METTL3-overexpressing MKN-45 and AGS cells. Representative images on the left, and quantification bars on the right in a–f (n = 3 for each group). g Mice with peritoneal implant nodes derived from METTL3-overexpressing (lvM3; n = 4) and control (lvCTL; n = 4) MKN-45 cells. h, i Curves of abdominal circumferences and body weights of the peritoneal metastasis models. j Representative pictures of the peritoneal implants from stable METTL3-overexpressing and control MKN-45 cells. k Number (left) and weight (right) of implanted nodes in peritonea of mouse models. Each dot represents one sample. l Representative pictures of METTL3 expression in peritoneal nodes by IHC. Data are presented as mean ± SD. *P < 0.05; **P < 0.01; ***P < 0.001; ****P < 0.0001.