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. 2020 Oct 9;10:16945. doi: 10.1038/s41598-020-73787-6

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Overall analysis process. (A) Identification of potential cancer-cell-extrinsic lncRNAs through analysis of bulk RNA-sequencing data from the BCCRC- and TCGA-LUAD cohorts. (B) Exploration of lncRNA expression in single-cell RNA sequencing data of immune cells isolated from lung tumour samples (E-MTAB-6149). (C) Analysis of lncRNA expression in healthy human immune cells (GSE60424). (D) Assessment of lncRNA-based anti-tumour activity in vitro through both immune activation and siRNA-based assays.