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. 2020 May 6;45(12):1986–1993. doi: 10.1038/s41386-020-0698-8

Fig. 2. Effects of acute or repeated treatment with MCAM on self-administration of fentanyl or cocaine.

Fig. 2

Panels a and b show effects of a single injection of 0.1 and 0.32 mg/kg MCAM, respectively; panel c shows effects of repeated injections of 0.32 mg/kg MCAM, with injections separated by 12 days. For all panels, n = 4 except for cocaine data in panel a which is n = 3 (see “Effects of acute MCAM administration” for more information). The number of infusions is plotted across consecutive days; symbols above “B” indicate data from the sessions preceding MCAM injection, whereas symbols above “T” indicate data from the session on the day of treatment (i.e., 60 min after MCAM injection) for panels a and b or the first MCAM injection in panel c. Symbols represent the mean (±1 SEM); filled symbols indicate data that are significantly different from baseline according to a Dunnett’s test (p < 0.05). The shaded region shows the range of the baseline sessions across individual monkeys, and the arrows and vertical dashed lines indicate the days on which MCAM was administered.