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. 2020 Jul 14;45(12):2106–2113. doi: 10.1038/s41386-020-0764-2

Fig. 4. Pomaglumetad blocks restraint stress-induced increase in DA neuron population activity.

Fig. 4

a Normal rats exposed to 2 h acute restraint stress following VEH pretreatment displayed increased DA neuron population activity compared to VEH-treated rats left in their home cage for 2 h. POM pretreatment (3 mg/kg, i.p.) normalized DA neuron population activity in rats that received restraint stress to control levels, which was not observed in rats that received both POM and the mGluR2/3 antagonist LY34 prior to restraint stress. b, c No significant changes were observed in DA neuron firing rate or percentage of spikes in bursts. *p < 0.05, **p < 0.01, ***p < 0.001 within groups #p < 0.05, ##p < 0.01, ###p < 0.001 between groups.