Table 1.

Genetic main effects in Tcf4tg and Tcf4Ex4δ^+/− mice in different environments.

Superdomain	Domain	Measure	Pglobal	EE environment tg/wt			IR environment tg/wt			SD environment tg/wt			IR environment Tcf4δEx4/wt†
				Effect tg	Statistic	P	Effect tg	Statistic	P	Effect tg	Statistic	P	Effect Tcf4δEx4	Statistic	P
COGNITIVE DOMAIN		m	*	−0.127	t80 = −0.438	0.663	−1.811	t86 = −2.890	0.005	−1.997	t82 = −4.372	<0.001	−1.632	t86 = −3.723	<0.001
Spatial Learning		m	*	0.015	t76 = 0.040	0.969	−4.103	t82 = −2.397	0.019	−3.899	t85 = −6.578	<0.001	−4.112	t82 = −6.670	<0.001
	Initial learning	m	*	−0.093	t50 = −0.128	0.899	−2.598	t54 = −1.469	0.148	−3.035	t56 = −3.378	0.001	−4.834	t54 = −4.815	<0.001
	Flexibility learning	m	*	−0.621	t50 = −0.849	0.400	−7.877	t54 = −2.919	0.005	−4.698	t56 = −6.020	<0.001	−6.862	t54 = −4.632	<0.001
	Recall	m	*	0.645	t50 = 1.210	0.232	0.002	t53 = 0.004	0.997	−4.321	t56 = −6.698	<0.001	−1.456	t26 = −1.682	0.105
Fear memory		m	*	−0.413	t54 = −0.939	0.352	−0.807	t58 = −2.056	0.044	0.068	t48 = 0.179	0.858	0.806	t53 = 1.433	0.158
	Context memory	m	*	−0.417	t52 = −0.830	0.410	−0.066	t58 = −0.144	0.886	−0.318	t23 = −1.129	0.271	0.763	t46 = 1.512	0.137
	Cue memory	m	*	−0.467	t52 = −0.729	0.469	−1.548	t58 = −3.437	0.001	0.453	t23 = 0.801	0.431	0.935	t54 = 1.585	0.119
	Social fear memory	m	ns	–	–	–	–	–	–	1.153	t56 = 2.099	0.040	–	–	–
Working memory	Working memory	u	*	0.104	t26 = 0.175	0.863	0.439	t28 = 0.581	0.566	−0.218	t28 = −0.300	0.767	−2.032	t28 = −2.666	0.013
AFFECTIVE DOMAIN		m	*	−0.922	t110 = −3.359	0.001	−0.389	t121 = −0.682	0.497	−0.159	t88 = −0.537	0.593	−0.018	t118 = −0.028	0.978
Pain sensitivity	Pain sensitivity	u	*	−1.032	t26 = −0.935	0.358	−0.773	t28 = −0.348	0.730	–	–	–	0.120	t28 = 0.098	0.923
Anxiety	Anxiety	m	*	−0.492	t54 = −1.251	0.216	−0.115	t58 = −0.490	0.626	0.371	t87 = 0.641	0.523	−0.829	t83 = −1.271	0.207
Curiosity	Curiosity	m	*	−1.994	t54 = −2.742	0.008	−1.560	t58 = −1.238	0.221	−0.486	t57 = −0.828	0.411	–	F1.0,27.2 = 0.251	0.621
Motivation	Motivation	m	*	−0.246	t54 = −0.403	0.689	0.115	t59 = 0.086	0.932	−0.439	t58 = −2.045	0.045	−0.142	t53 = −0.287	0.775
ACTIVITY DOMAIN		m	*	−0.418	t54 = −0.824	0.413	−0.224	t60 = −0.266	0.791	0.163	t58 = 0.560	0.577	0.490	t58 = 1.070	0.289
Hyperactivity		m	*	−0.418	t54 = −0.824	0.413	−0.224	t60 = −0.266	0.791	0.163	t58 = 0.560	0.577	0.490	t58 = 1.070	0.289
	Ambulation	m	*	0.409	t110 = 0.890	0.376	−0.768	t119 = −0.919	0.360	0.776	t117 = 1.205	0.231	0.447	t113 = 0.832	0.407
	Speed	m	*	−1.238	t52 = −1.553	0.127	−0.087	t55 = −0.071	0.944	−0.413	t56 = −1.180	0.243	0.380	t56 = 0.944	0.349

Significant differences are marked in bold and with stars in the case of Pglobal. Numbers of degrees of freedom are marked for each statistic in subscript. Statistics depicted are from the multivariate analyses (see Supplementary Table 1 for all details).