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. 2020 Oct 9;5:232. doi: 10.1038/s41392-020-00336-y

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — Mutant p53 inhibits tumorigenesis by avoiding the initiation of oncogenic WNT signaling pathway. However, when mutant p53 is exposed to gallic acid, which is a polyphenol metabolite produced by gut commensal microbes, it loses its tumor-suppressive property and switches to perform oncogenic functions by over-activating WNT signaling pathway to enhance proliferation and invasion of tumor cells