Table 3.
Effect of ApoE Alleles on Lipid Profile and Dyslipidemia of T2DM Patients
| Variables | E2 (n= 30) | E3 (n= 118) | E4 (n= 20) | P-value |
|---|---|---|---|---|
| Age, (years) | 56.9 ± 8.8 | 53.3 ± 9.5 | 53.1 ± 12.7 | 0.19 |
| BMI (kg/m2) | 29.4 ± 4.4 | 28.7 ± 5.8 | 28.6 ± 5.3 | 0.84 |
| Glucose (mg/dL) | 188.7 ± 80.9 | 176.0± 55.8 | 171 ± 39.9 | 0.73 |
| Total cholesterol (mg/dL) | 186.9 ± 37.7 | 206.9 ± 54 | 188.7 ± 43 | 0.07 |
| Triglycerides (mg/dL) | 217.6 ± 131.1 | 183.5 ± 50.2 | 189.3 ± 61.7 | 0.16 |
| HDL-c (mg/dL) | 45.7 ± 9 | 42.5 ± 11.6 | 38.8 ± 10 | 0.11 |
| VLDL (mg/dL) | 35.5 ± 14.4 | 37.6 ± 17.9 | 32.4 ± 12 | 0.54 |
| LDL-c (mg/dL) | 94.6 ± 44.7† | 120.9 ± 56.5 | 126.5 ± 40.3 | 0.04 |
| HOMA-IR | 6.55 ± 2.0* | 4.33 ± 3.1 | 3.5 ± 2.1 | 0.002 |
| Dyslipidemia n (%) | ||||
| Hypercholesterolemia | 14 (46.7) | 65 (55.1) | 7 (35) | 0.21 |
| Hypertriglyceridemia | 19 (63.3) | 88 (74.6) | 13 (65) | 0.37 |
| Hypoalphalipoproteinemia | 7 (23.3) | 48 (40.7) | 11 (55) | 0.06 |
| High LDL-c | 7 (23.3) | 50 (42.4) | 6 (30) | 0.12 |
Notes: E2: e2e2 + e2e3 + e2e4; E3: e3e3; E4: e3e4 + e4e4. †E2 vs E4, p<0.05; *E2 vs E3, p < 0.05; E2 vs E4, p<0.05.
Abbreviations: BMI, body mass index; HDL-c, high-density lipoprotein cholesterol; VLDL-c; very low-density lipoprotein cholesterol; LDL-c, low-density lipoprotein cholesterol, HOMA-IR; homeostatic measurement assessment-insulin resistance; T2DM, type 2 diabetes mellitus.