Table 1.
Demographics, Comorbidities, Invasive Procedures and Mortality of Patients with Carbapenem-Resistant Klebsiella pneumoniae Infections
| n = 135 | CT1313 (n=35) |
CT1291 (n=20) |
CT3176 (n=14) |
CT1814 (n=13) |
CT2410 (n=11) |
The other CTs (n=42) |
p value* |
|---|---|---|---|---|---|---|---|
| Age in years, mean ± SD | 68.63±20.65 | 65.85±19.14 | 72.64±15.29 | 64.92±15.14 | 67.55±15.79 | 64.81±15.73 | 0.994 |
| Gender (Male) | 28(80.0%) | 14(70.0%) | 12(85.7%) | 11(84.6%) | 6(54.5%) | 30(71.4%) | 0.423 |
| Bacteremia | 9(25.7%) | 8(40.0%) | 2(14.3%) | 1(7.7%) | 1(9.0%) | 5(11.9%) | 0.075 |
| Pulmonary infection | 30(85.7%) | 18(90.0%) | 10(71.4%) | 12(92.3%) | 9(81.8%) | 37(88.1%) | 0.629 |
| Urinary infection | 6(17.1%) | 6(30.0%) | 2(14.3%) | 1(7.7%) | 3(27.3%) | 3(7.1%) | 0.200 |
| Abdominal infection | 5(14.3%) | 3(15%) | 0(0.0%) | 0(0.0%) | 0(0.0%) | 5(11.9%) | 0.323 |
| Cerebral vascular disease | 22(62.9%) | 12(60%) | 4(28.6%) | 7(53.8%) | 5(45.5%) | 22(52.4%) | 0.372 |
| Hypertension | 21(60.0%) | 13(65.0%) | 9(64.3%) | 8(61.5%) | 5(45.5%) | 32(76.2%) | 0.463 |
| Diabetes | 11(31.4%) | 6(30.0%) | 8(57.1%) | 7(53.8%) | 4(36.4%) | 17(40.5%) | 0.451 |
| Mechanical ventilation | 27(77.1%) | 14(70.0%) | 9(64.3%) | 10(76.9%) | 6(54.5%) | 27(64.3%) | 0.681 |
| Central venous catheter | 18(51.4%)a | 7(35.0%)a | 11(78.6%) | 11(84.6%)a | 6(54.5%) | 27(64.3%) | 0.035+ |
| Foley catheter | 23(65.7%) | 16(80.0%) | 13(92.9%) | 12(92.3%) | 8(72.7%) | 32(76.2%) | 0.264 |
| Nasogastric tube | 24(68.6%) | 11(55.0%) | 12(85.7%) | 7(53.8%) | 7(63.6%) | 27(64.3%) | 0.486 |
| Continuous renal replacement therapy | 6(17.1%) | 4(20.0%) | 0(0.0%) | 2(15.4%) | 2(18.2%) | 3(7.1%) | 0.391 |
| All cause in-hospital mortality | 13(37.1%)a | 4(20.0%)a | 11(78.6%)a | 1(7.7%)a | 6(54.5%) | 13(31.0%)a | 0.001+ |
| Charlson comorbidity indexb | 4.72±0.81 | 3.55±0.61 | 3.91±0.63 | 4.41±0.69 | 3.88±0.46 | 2.74±0.77 | 0.232 |
| Pitt Bacteremia Scorec | 3.50±0.51 | 2.80±0.64 | 2.64±0.59 | 3.92±0.54 | 3.55±0.79 | 2.81±0.73 | 0.211 |
Notes: aThese data were significant using pairwise analyses: CT3176 vs CT1313 (All cause in-hospital mortality; P = 0.012); CT3176 vs CT1291 (All cause in-hospital mortality; P = 0.001); CT3176 vs CT1814 (All cause in-hospital mortality; P = 0.0003); CT3176 vs The other CTs (All cause in-hospital mortality; P = 0.004); CT1814 vs CT1313 (Central venous catheter; P = 0.049); CT1814 vs CT1291 (Central venous catheter; P = 0.011); bCharlson comorbidity index. The charlson comorbidity index can range from 0 to 37. (A patient <40 who has no other medical or surgical conditions would have a score of 0; an 81-year-old with AIDS and cancer would have a score of 37). cA Pitt bacteremia score >4 indicates severe illness. The Pitt bacteremia score is based on temperature, hypotension, mental status, and presence or absence of mechanical ventilation. *p values are for comparisons between CTs. Dichotomous variables are analyzed using Fisher’s exact test and continuous variables are analyzed using one-way ANOVA. +The bolded numbers correspond to highlighted parameters in the article.
Abbreviation: CT, complex type.