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. 2020 Oct 6;16:2285–2296. doi: 10.2147/NDT.S265601

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© 2020 Liu and Dong.

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NR4A2 regulates miR-652 expression through transcriptional inhibition. (A) miR-652 expression in rat brain tissues and PC12 cells measured by RT-qPCR; (B) the binding sites between NR4A2 and miR-652 promoter predicted by the JASPAR website; (C) conserved binding sequences between NR4A2 and miR-652; (D) ChIP-qPCR detection of NR4A2 binding to miR-652 promoters. All values were expressed as means ± SD from three independent experiments. Unpaired t-test (panel (A) left) or one-way (panel (A) right and (D) followed by Tukey’s post hoc test was utilized for comparison. ^##p < 0.01 vs sham-operated rats; *p < 0.05 vs PC12 cells transfected with Lv-NC or Scr or the IgG group.